The Project
A collaboration between All India Institute of Medical Sciences, University of Delhi South Campus and Bioheaven 360 Genotech Pvt. Ltd. and funded by Department of Biotechnology(DBT), India. We aim to understand the genetic and physicochemical aspects of Osteoporosis and develop tools to stratify patients for effective treatment. The project will culminate in the development of Vajra A.I. platform which is our "Venture in Artificial Intelligence-Jig for Risk Assessment of Osteoporosis".
Mission
We strive to develop tools for Predictive Risk Assessment of osteoporosis using Biochemical, Radiological and Genomic data.
Objectives
- Collection of biochemical, radiological and genomic data for Indian patients followed by marker development.
- Genetic screening of Indian population for markers associated with osteoporosis.
- Development of AI based predictive risk assessment tool.
Collaborators
Our Team
Dr. Vijay Sharma
Project Coordinator, Professor, Aiims
Dr. Saurabh Raghuvanshi
Principal Investigator, Assoc. Professor, Udsc
Dr. Shailendra Vyas
Principal Investigator, Director, Bioheaven360
Dayon K
Biomedical Scientist, Bioheaven360
Pratyush Behere
Data Scientist, UDSC
Raju Singh
Technical Assistant, Aiims
Osteoporosis
Osteoporosis is a disease that occurs when the body loses bone mass leading to weaker bones with an increased risk of fracture. The bones can become so brittle that a fall or even mild stresses can cause fracture. Hip, wrist and spine are most commonly affected. It often goes undiagnosed as the process is slow with no visible symptoms.
Risk factors
- Gender: Women are more likely to develop osteoporosis than men.
- Age: Older individuals have a greater risk of osteoporosis.
- Family history: If you have a parent or sibling with osteoporosis then the risk of you having osteoporosis is greater.
- Dietary Factors: Low calcium intake, being underweight and low vitamin D intake can increase the risk of osteoporosis.
- Drugs and Medications: Long term use of corticosteroid medications or medications for seizures, cancer, transplant rejection and gastric reflux is also associated with high prevalanec of osteoporosis.
- Medical Conditions: People with cancer, lupus, kidney or liver disease, rheumatoid arthritis, inflammatory bowel disease, celiac disease, multiple myeloma have a higher risk of osteoporosis.
- Lifestyle: A sedentary lifestyle, alcohol and tobacco consumption increases the risk of osteoporosis.
Prevention
- Diet:A healthy balanced diet with calcium and vitamin D intake is necessary to reduce the risk of osteoporosis.
- Exercise:A combination of strength training exercises along with weight-bearing and balance exercises can be helpful in strengthening bones if done regularly.
Osteoporosis Papers and Reports
Osteoporosis Review by National Institutes of Health Osteoporosis and Related Bone Diseases National Resource Center
WHO Scientific Group On The Assessment Of Osteoporosis At Primary Health Care Level - Summary Meeting Report Brussels, Belgium, 5-7 May 2004
Address
University of Delhi South Campus
Website
genomeindia.du.ac.in
saurabh@genomeindia.org